«El debate del anciano y el joven» de Yisḥaq ibn Pulgar ha sido estudiado como parte de `Ezer ha-dat y en relación con la polémica religiosa que su autor mantuvo con Abner de Burgos/Alfonso de Valladolid. Pero la tradición manuscrita permite también el análisis de esta disputa como un texto que circuló de manera independiente. Desde esta perspectiva, se propone una lectura de esta versión que, atendiendo a aspectos formales y de contenido, ofrece nuevas claves de interpretación en el marco (...) de los debates religiosos de las comunidades judías en los s. XIII-XIV y revela las estrategias con las que el autor expone y defiende su propia posición ideológica. (shrink)

Information from forensic genetic tests of crime scene samples has been used to make claims about suspects' race and appearance. This article discusses and critiques the techniques used to make such claims, and raises policy concerns about them.

Human genomics is a translational field spanning research, clinical care, public health, and direct-to-consumer testing. However, law differs across these domains on issues including liability, consent, promoting quality of analysis and interpretation, and safeguarding privacy. Genomic activities crossing domains can thus encounter confusion and conflicts among these approaches. This paper suggests how to resolve these conflicts while protecting the rights and interests of individuals sequenced. Translational genomics requires this more translational approach to law.

There are very few (published) accounts of editorial misconduct, and those that do exist are almost exclusively focused on medicine-related areas. In the present article we detail a case of editorial misconduct in a rather underexplored domain, the social sciences. This case demonstrates that although legal systems provide different instruments of protection to avoid, compensate for, and punish misconduct on the part of journal editors, the social and economic power unbalance between authors and publishers suggests the importance of alternative solutions (...) before or instead of bringing a lawsuit to court. It puts forward strong arguments in favour of the need for effective regulatory bodies so as to achieve and maintain a culture of research integrity by all involved in the process. (shrink)

This article argues that current data for the safety and efficacy of fecal microbiota transplants as a treatment for any indication, including recurrent Clostridioides difficile infection, is low-quality. It develops a governance proposal that encourages production of high-quality evidence by incentivizing well-designed RCTs of stool and stoolderived microbial products. The proposal would require that FDA change its current enforcement approach, but it would not require any change in statutes or regulations.

In lieu of an abstract, here is a brief excerpt of the content:Reclaiming the Works of Early Modern Women Authorship, Gender, and Interpretation in the Nouveau recueil de lettres des dames de ce temps (1635)1Aurora Wolfgang (bio) and Sharon Diane Nell (bio)Reclaiming the forgotten texts of women writers has been a major feminist undertaking of the last half-century. Indeed, believing in the importance of this sort of work, we have each spent much of our careers studying the women writers absent (...) from our own graduate-school education. What follows, however, is a cautionary tale about discovery and reclamation: first, our discovery of what we thought was a hitherto-neglected text by eminent seventeenth-century writer Madeleine de Scudéry—her Lettres amoureuses de divers auteurs de ce temps (1641); second, our discovery that the text was not (even as indexed in Gerritsen Collection of Women’s History microfilm collection) authored by Scudéry but was written instead by a Franciscan priest, Jacques Du Bosc. Clearly, our second discovery pointed out both our own rush to judgment as well as that of other literary scholars interested in the tenuous project of historical reclamation. In this essay, we seek to explore the implications of attribution and authorship for our cautionary tale. Does the fact that a work is not Scudéry’s Lettres amoureuses but instead Du Bosc’s Nouveau recueil de lettres des dames de ce temps (1635) diminish its importance to the history of women’s letters?The First DiscoveryWe became interested in Scudéry’s Lettres amoureuses because of a brief description of the text in Joan DeJean’s Tender Geographies, a pioneering study of women novelists of the seventeenth century. DeJean describes a one-volume work that constituted the first publication of one of the most important writers of the seventeenth century, Madeleine de Scudéry. This work was a reversal of and “forceful response to” the so-called Ovidian model of epistolary fiction in which a “seduced and abandoned” woman complains in letter form about the infidelity of her male lover. In Scudéry’s text, however, men wrote long letters complaining about the women who did not reciprocate their love (DeJean, Tender Geographies 79).We obtained a copy of the Lettres amoureuses from the Women’s History microfilm collection, which was created in the 1970s (published 1983) in order to make available [End Page 1] an extensive array of texts and documents relating to women’s lives. We were surprised to see that all of the letters in the Lettres amoureuses were written by women—not men. Moreover, most of the letters were written by women to other women. No letters by men were included at all. Our copy of Lettres amoureuses contained letters and responses written between women, meant to show the excellence of women’s writing skill. The letters discussed and debated a wide variety of topics of interest to seventeenth-century French women; more strikingly, however, they reflected a close-knit homosocial world of women who openly expressed love, devotion, desire, and longing for each other’s company.Given the differences between our copy of Lettres amoureuses and the text described by DeJean, we wondered if we were looking at the same book. Was our collection the one to which DeJean referred? Yes and no. In another DeJean article about the Lettres amoureuses, we discovered that DeJean had used a particular copy of the text, one found in the holdings of Harvard’s Houghton Library. Upon first obtaining a microfilm copy of the Houghton volume, and later examining the physical book itself in Houghton’s rare books room, we saw that it (unlike our own copy) did indeed contain only letters by men who complain about their female beloveds. At this point, we thought we had discovered a second volume to Scudéry’s work: it seemed clear to us that the Lettres amoureuses had been halved at some point in the last several centuries and that we had a chance to reunite the volumes. After all, the preface in the Houghton volume tells the reader, “Si vous receuez fauorablement ce volume, ie vous en prepare un second” [“If you receive this volume favorably, I will prepare a second one... (shrink)

In the opening years of the 21st century, it became fashionable to describe the human genome as belonging to the common heritage of humanity. The United Nations, in its Universal Declaration on the Human Genome and Human Rights, now identifies the human genome as part of the common heritage, as does the international Human Genome Organization and the Council of Europe. The common heritage concept has played a prominent role in arguments against patenting the human genome or portions thereof. This (...) essay considers whether the common heritage designation will advance the political and legal goals of its proponents. (shrink)

Phenomenology and structuralism are commonly understood as two opposing and largely incompatible schools of thought. Indeed, if the former is thought of as the philosophy of subjectivity par excellence, and the latter as the tradition in which the “death of man” is declared, it seems difficult to challenge the antagony between them. On closer inspection, however, it becomes clear that this picture represents an oversimplification and turns out to be, to a great extent, fallacious. The aim of this paper is (...) to show that the philosophy of the early Husserl – notably as exposed in the Logical Investigations – ought to be fully considered as both part of the wide tradition of Transcendental philosophy as well as Structuralism. To this end, the paper mainly addresses Husserl’s notion of Wissenschaftslehre and the mereology developed in the Third logical investigation and, as a result, tries to show how Husserl’s position can be defined in terms of a “phenomenological structuralism” or a “structural phenomenology” or, as I propose, a “transcendental structuralism”. (shrink)

This essay identifies two legal lineages underlying the common heritage concept, and applies each to the human genome. The essay notes some advantages and disadvantages of each approach, and argues that patenting of human genes would be allowable under either approach.

The phenomenon of cheating in higher education is of overwhelming importance in that the students engaging in these acts are unlikely to have the skills necessary for their future professional life. Despite its relevance, the empirical evaluation of cheating in universities has been almost exclusively focused on the US context. Little is known about cheating at the European level, let alone in Portugal. Even less is explored at the regional level. In this paper we present evidence on the perception of (...) cheating by Portuguese undergraduate students of economics/business degrees. We undertake a large-scale survey, involving 2675 students from all Portuguese mainland public universities. We found that copying-favourable environments are associated with a higher propensity to cheat. Moreover, in universities where ‘codes of honour’ exist, this propensity tends to be lower. Finally, the propensity to copy seems to be highly influenced by the cultural systems and socially-related factors of different regions. (shrink)

This particular roundtable falls at the end of a four-year networking project (COST Action IS1307 New Materialism: Networking European Scholarship on ‘How Matter Comes to Matter’) and reflects upon the genealogies of new materialism and how these flow into the individual working practices of participants. The texts below were contributed remotely via email by members of the group, following face-to-face meetings in Barcelona, Maribor, Warsaw, Liverpool, Paris and Utrecht. Authors were unaware of each other’s responses and in this way the (...) dialogue has unfolded a little like a game of Exquisite Corpse or Consequences, with questions acting like a trail of breadcrumbs to follow. Accordingly, the text is the product of a partially bounded experimental system ‘designed to give unknown answers to questions that the experimenters themselves are not yet able to clearly ask’ (Rheinberger 1997: 28). Thus, it both ruminates upon work to date and is intended to generate novel responses from authors and readers alike. (shrink)

In appearance, Husserl’s writings seem not to have had any influence on linguistic research, nor does what the German philosopher wrote about language seem to be worth a place in the history of linguistics. The purpose of the paper is exactly to contrast this view, by reassessing both the position and the role of Husserl’s early masterpiece — the Logical Investigations — within the history of linguistics. To this end, I will focus mainly on the third (On the theory of (...) wholes and parts) and fourth (The distinction between independent and non-independent meanings) Investigations, paying special attention to Husserl’s mereology and to the idea of a general pure grammar. The paper tries to situate the third and fourth Logical Investigation within the general context of late nineteenth-century and early twentieth-century linguistics and furthermore attempts to show the historical and theoretical importance of the Logical Investigations for the birth and the development of one of the most important linguistic “schools” of the twentieth century, namely structural linguistics. (shrink)

“DNAPrint Genomics, Inc. has applied the most recent advancements in human genomic technology for the deciphering of an individual's race. We are proud to introduce to the forensic community DNA WITNESS 2.0, a genetic test for the deduction of the heritable component of race, called Biogeographical Ancestry.”–Z. Gaskin“One definite and obvious consequence of the complexity of human demographic history is that races in any meaningful sense of the term do not exist in the human species.”–D. B. Goldstein and L. Chikhi.

The paper’s purpose consists in pointing out the importance of the notion of “territory”, in its different accepted meanings, for the development of a theory and a practice of subjectivity both in deleuzean and canettian thought. Even though they start from very different perspectives and epistemic levels, they indeed produce similar philosophical effects, which strengthen their “common” view and the model of subjectivity they try to shape. More precisely, the paper focuses on the deleuzean triad of territorialisation, deterritorialisation, reterritorialisation, with (...) regard to the role it plays in the forming of the subject and in connection with the fundamental deleuzean notion of difference; it furthermore concentrates on the characterization of the notion of territory in Canetti’s work, also in the light of the mentioned deleuzean categories and with reference to the crucial canettian concept of transformation. Finally, the paper analyses both the political consequences of the “nomadic subjectivity” Deleuze and Canetti deal with and the critical and problematic aspects it involves. (shrink)

The biosciences have become information sciences, in which knowledge is often produced in silica, by the manipulation and analysis of large datasets. Genomics has been at the forefront of the data explosion and is a model for bioscience as a large-scale endeavor. Large genome research datasets are frequently shared through research repositories. To protect the interests of people from whom the data were derived , human data are often shared through a controlled access mechanism, in which data repositories can, in (...) theory, place limitations on who uses the data and for what purpose. Controlled access is an innovative governance mechanism, but it may not protect data sources the way policy makers intended. Here, I describe one controlled access process in some detail, and provide insight into how and why researchers fail to comply with data use restrictions. (shrink)

Aurora P. Jackson and Richard Scheines. Single Mother's Efficacy, Parenting in the Home Environment, and Children's Development in a Two-Wave Study.

Biomedical research is increasingly data intensive and computational, and “big data science” is migrating into the clinical arena. Unfortunately, ethicists, regulators, and policy‐makers have barely begun to explore the ethical, legal, and social issues raised by the variety of analytical and computational approaches in use and under development in biology and medicine. Most scholarship concerning big data bioscience has focused on privacy, a vitally important consideration but not the only one. Among the issues raised by new computational technologies are questions (...) about safety and safety assessment, justice, and how to obtain proper informed consent. These technologies also raise a myriad of regulatory issues that could influence the probability of translating new assays or computational tools to the clinical or public health spheres. (shrink)

Ontology is critically assessed as being too narrowly based to contribute substantially to our understanding of the real world. Ontology reflects only what amounts to an extended notion of an object, whereas understanding the real world requires, in addition, the concepts of process, event, and state of affairs. Formal relationships among the four reality concepts are presented and the privileging of any one of them is rejected, the use of the |State of Affairs System leads to a parsimonious formulation of (...) the nature of persons as states of affairs rather than objects. In passing, the notion that states of affairs cannot be located is rejected and the significance of the State of Affairs System for scientific and metaphysical theorizing is noted. (shrink)

The paper argues that ecology should not be understood as a sectoral issue, i.e. as the object of specific scientific disciplines such as environmental sociology, geology or biology; on the contrary, it is by very nature that ecology should be regarded as a large-scale matter consisting first and foremost in philosophical and political questions. It is the paper’s main objective to claim that there is no way out from the ecological crisis without a critical reconsideration of the dominant socio-economic structures (...) and of the cultural and philosophical background underpinning them. To this end, the present paper resorts to the concept of “social metabolism”. By applying it to various “immaterial elements”, and notably to philosophical systems, the essay investigates their ecological impact. As the paper aims to show, the metabolic analysis of the philosophical system implies adopting and advocating for a renewed transcendental approach. (shrink)

Therapeutic alliance is a central concept in psychotherapeutic work. The relationship between the therapist and the patient plays an important role in the therapeutic process and outcome. In this article, we investigate how therapists work with disaffiliation resulting from enduring disagreement while maintaining an orientation to the psychotherapeutic project at hand. Data come from a total of 18 sessions of two dyads undergoing psychoanalytic psychotherapy and is analyzed with conversation analysis. We found that collaborative moves deployed amidst enduring disagreement can (...) assist the therapist in furthering the disagreement as part of the ongoing psychotherapeutic project. Relying on their collaborative format, therapists utilize collaborative moves to temporarily mend the disaffiliation without necessarily changing their position and re-affiliating with the patient. We show how the relation between the therapist and the patient gets transformed in the moment-by-moment work accomplished in the psychotherapeutic talk. (shrink)

The prelims comprise: Introduction Background on Patent Law: Fighting the Myths and Misconceptions The Ethics of Patenting Human Genes.

_Abstract_: In this paper we carve out a _reformist_ agenda within the debate on the foundations of cognitive science, incorporating some important ideas from the 4E cognition literature into the computational-representational framework. We are deeply sympathetic to this reformist program since we think that, despite strong criticism of the concept of computation and the related notion of representation, computational models should still be at the core of the study of mind. At the same time, we recognize the need for a (...) liberalization of the computational and representational framework that can address deep dissatisfaction with the anti-biologism and radical internalism of classical cognitive science. However, reform is a difficult task, so in this article we focus on two open questions within the reformist agenda. The first concerns the possibility of combining mechanistic-computational and dynamical explanations. The second concerns related changes in the notion of representation and its use (with special attention to Andy Clark’s radical predictive processing). _Keywords_: Continuum of Representational Genera;_ _Enactivism; Predictive Processing; Radical Embodied Cognition Thesis; Representationalism _ Due problemi aperti nell’agenda riformista della filosofia della scienza cognitiva _ _Riassunto_: In questo lavoro identifichiamo un’agenda _riformista_ nel dibattito sui fondamenti della scienza cognitiva che incorpora alcune idee centrali provenienti dalla letteratura sulla cognizione 4E all’interno di una cornice computazionalista e rappresentazionalista. Tale agenda considera il quadro computazionalista e rappresentazionalista ancora imprescindibile ai fini dello studio integrato della mente e del cervello, ma ne persegue una liberalizzazione nell’intento di renderlo idoneo ad accogliere alcuni importanti spunti emersi dalla letteratura sulla cognizione delle 4E. Tuttavia, riformare è un compito difficile. In questo articolo ci concentriamo su due problemi aperti nell’agenda riformista. Il primo riguarda la possibilità di mettere assieme le spiegazioni meccaniciste e computazionaliste con quelle dinamiche. Il secondo riguarda i cambiamenti relativi alla nozione di rappresentazione e al suo impiego (con particolare attenzione all’elaborazione predittiva radicale di Andy Clark). _Parole chiave_: Continuum dei generi rappresentazionali;_ _Elaborazione predittiva; Enattivismo; Tesi della cognizione incarnata radicale; Rappresentazionalismo. (shrink)